Ion Channels and Salt Bridges: Quantum Calculations Show Unusual Effects
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چکیده
منابع مشابه
Quantum Calculations Show Caution Is Needed In Interpreting Methanethiosulfonate Accessibility Experiments On Ion Channels
Standard models of ion channel voltage gating require substantial movement of one transmembrane segment, S4, of the voltage sensing domain. Evidence comes from the accessibility to external methanethiosulfonate (MTS) reagents of the positively charged arginine residues (R) on this segment. These are first mutated to cysteines (C), which in turn react with MTS reagents; it is assumed that the C ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.657